Women with dcis treated with lumpectomy and radiation therapy who are considering tamoxifen to reduce the incidence of a second breast cancer event should assess the risks and benefits of therapy, since treatment with tamoxifen decreased the incidence of invasive breast cancer, but has not been shown to affect survival see table 1 in clinical pharmacology .

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sperm motility was not improved by tamoxifen treatment.

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clinical experience in the second-line breast cancer trials ar bc2 and ar bc3 indicates that the therapeutic effect of femara therapy is not impaired if femara is administered immediately after tamoxifen.

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lipid study in a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer at 24 months comparing the effects on lipid profiles of adjuvant letrozole to tamoxifen, 12 of patients on letrozole had at least one total cholesterol value of a higher ctcae grade than at baseline compared with 4 of patients on tamoxifen.


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